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- Product overview
Treating moderate to severe hot flashes caused by menopause. Certain doses of Angeliq are also used to treat moderate to severe dryness, itching, and burning in or around the vagina. Angeliq may also be used for other conditions as determined by your doctor.
Angeliq is a combination of progestin and estrogen hormones. It works by replacing natural progestin and estrogen in women who can no longer produce enough of these hormones.
Do NOT use Angeliq if:
- you are allergic to any ingredient in Angeliq
- you have had a severe reaction (eg, swelling of the hands, face, lips, eyes, throat, or tongue; trouble swallowing or breathing; hoarseness) after taking Angeliq
- you are pregnant, think you may be pregnant, or plan to become pregnant
- you have kidney, liver, or adrenal gland problems
- you have known or suspected breast cancer or another estrogen-dependent cancer, or you have a history of breast cancer
- you have abnormal vaginal bleeding of an unknown cause
- you have active blood clots (eg, of the legs or lungs), a history of blood clots, or a condition which may increase your risk of blood clots
- you have had a stroke or heart attack within the past year
- you have had your uterus removed (hysterectomy)
- you are taking boceprevir
Contact your doctor or health care provider right away if any of these apply to you.
Before using Angeliq:
Some medical conditions may interact with Angeliq. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have a condition called hereditary angioedema
- if you have a history of uterus problems (eg, endometriosis, fibroids, abnormal vaginal bleeding)
- if you have a history of abnormal mammograms or lumps in the breast, or if a member of your family has had breast cancer
- if you have a history of asthma; heart problems (eg, heart failure); high blood pressure; the blood problem porphyria; blood vessel problems; heart attack; stroke; high cholesterol or triglyceride levels; diabetes; depression; gallbladder problems; pancreas problems; cancer; growths in the liver; kidney, liver, or adrenal gland problems; lupus; memory problems; migraine headaches; seizures; thyroid problems; or chorea (jerky, involuntary movements of the face, arms, or legs)
- if you have high blood potassium levels, low blood sodium levels, low parathyroid gland function, or high blood calcium levels
- if you have a history of jaundice (yellowing of the eyes or skin) caused by pregnancy or estrogen use
- if you drink alcohol, smoke, use tobacco, are very overweight, will be having surgery, or will be confined to a bed or chair for a period of time
- if a member of your family has a history of blood clots (eg, in the leg or lungs), lupus, or has been very overweight
Some MEDICINES MAY INTERACT with Angeliq. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Troleandomycin because the risk of jaundice (yellowing of the skin or eyes) may be increased
- Tranexamic acid because the risk of blood clots may be increased
- Angiotensin-converting enzyme (ACE) inhibitors (eg, lisinopril), angiotensin receptor blockers (eg, valsartan), eplerenone, heparin, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), potassium-sparing diuretics (eg, triamterene), or potassium supplements because the risk of high potassium levels in the blood may be increased
- Azole antifungals (eg, itraconazole, ketoconazole), macrolide antibiotics (eg, clarithromycin, erythromycin), or protease inhibitors (eg, boceprevir, ritonavir) because they may increase the risk of Angeliq's side effects
- Aprepitant, barbiturates (eg, phenobarbital, primidone), carbamazepine, clobazam, efavirenz, felbamate, fosaprepitant, griseofulvin, hydantoins (eg, phenytoin), mifepristone, penicillins (eg, amoxicillin), rifamycins (eg, rifampin), rufinamide, St. John's wort, or tetracyclines (eg, doxycycline) because they may decrease Angeliq's effectiveness
- Corticosteroids (eg, prednisone) because the risk of their side effects may be increased by Angeliq
- Lamotrigine, thyroid hormones (eg, levothyroxine), or valproic acid because their effectiveness may be decreased by Angeliq
This may not be a complete list of all interactions that may occur. Ask your health care provider if Angeliq may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use Angeliq:
Use Angeliq as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with Angeliq. Talk to your pharmacist if you have questions about this information.
- Take Angeliq by mouth with or without food.
- Swallow Angeliq whole with some liquid. Do not break, crush, dissolve, or chew before swallowing. If you cannot swallow Angeliq whole, tell your doctor. You may need a different medicine.
- Grapefruit and grapefruit juice may increase the risk of side effects from Angeliq. Talk to your doctor before including grapefruit or grapefruit juice in your diet while taking Angeliq.
- Take Angeliq on a regular schedule to get the most benefit from it.
- Taking Angeliq at the same time each day will help you remember to take it.
- Continue to take Angeliq even if you feel well. Do not miss any doses.
- If you miss a dose of Angeliq, take it as soon as possible. If more than 24 hours have passed since you missed a dose of Angeliq, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.
Ask your health care provider any questions you may have about how to use Angeliq.
Important safety information:
- Check with your doctor before you use a salt substitute or a product that has potassium in it.
- Angeliq may increase the risk of stroke, heart attack, blood clots, high blood pressure, or similar problems. The risk may be greater if you smoke.
- Tell your doctor or dentist that you take Angeliq before you receive any medical or dental care, emergency care, or surgery. If you will be having surgery or will be confined to a chair or bed for a long period of time (eg, a long plane flight), notify your doctor at least 4 to 6 weeks beforehand. You may need to stop using Angeliq or take other special precautions for a period of time.
- Angeliq may cause dark skin patches on your face (melasma). Exposure to the sun may make these patches darker. Ask your doctor whether you should use sunscreen or wear protective clothing when your skin is exposed to the sun, sunlamps, or tanning booths.
- If you wear contact lenses and you develop problems with them or your vision, contact your doctor as soon as possible.
- Angeliq may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking Angeliq.
- Diabetes patients - Angeliq may affect your blood sugar. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- You should talk to your doctor regularly (eg, every 3 to 6 months) to determine whether or not you still need to take Angeliq.
- Lab tests, including blood pressure and blood potassium levels, may be performed while you use Angeliq. You should have breast and pelvic exams, and a Pap test at least once a year. You should also have periodic mammograms as determined by your doctor. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- You should perform monthly self-breast exams while you are taking Angeliq. Talk with your doctor if you are unsure how to properly perform a self-breast exam. Report any lumps to your doctor right away.
- Use Angeliq with caution in the ELDERLY; they may be more sensitive to its effects.
- Angeliq is not approved for use in CHILDREN; safety and effectiveness in children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: Do not use Angeliq if you are pregnant. If you think you may be pregnant, contact your doctor right away. Angeliq is found in breast milk. If you are or will be breast-feeding while you use Angeliq, check with your doctor. Discuss any possible risks to your baby.