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Ciclospray
$13.75 USD
Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco for asthma and Omnaris/Omniair for hayfever in the US & Canada. Phase 3 trials for the hayfever indication outside the US are ongoing.
8.95$. Delivery period 14-21 days.
Free for orders more than $200.00 USD
27.95$. Delivery period 5-7 days.
Free for orders more than $300.00 USD
8.95$. Delivery period 14-21 days.Free for orders more than $200.00 USD
27.95$. Delivery period 5-7 days.Free for orders more than $300.00 USD
Ciclospray 50 mcg
| Name | Quantity | Price Each | Total Price | Save | |
|---|---|---|---|---|---|
| Ciclospray 50 mcg | 1 pills | $22.00 USD | $22.00 USD | ||
| Ciclospray 50 mcg | 2 bottles | $20.90 USD | $41.80 USD + Bonus - 3 pills | $2.20 USD | |
| Ciclospray 50 mcg | 3 bottles | $19.86 USD | $59.58 USD + Bonus - 3 pills | $6.42 USD | |
| Ciclospray 50 mcg | 4 bottles | $18.86 USD | $75.44 USD + Bonus - 6 pills | $12.56 USD | |
| Ciclospray 50 mcg | 5 bottles | $16.98 USD | $84.90 USD + Bonus - 6 pills | $25.10 USD | |
| Ciclospray 50 mcg | 6 bottles | $15.28 USD | $91.68 USD + Bonus - 6 pills | $40.32 USD | |
| Ciclospray 50 mcg | 10 bottles | $13.75 USD | $137.50 USD + Bonus - 12 pills | $82.50 USD |
- Product overview
Ciclesonide is a glucocorticoid used to treat obstructive airway diseases. It is marketed under the brand name Alvesco for asthma and Omnaris/Omniair for hayfever in the US & Canada. Phase 3 trials for the hayfever indication outside the US are ongoing.
Pharmacokinetics
Absorption
Prodrug converted to active metabolite, des-ciclesonide, after topical administration. Negligible serum concentrations following intranasal administration. Des-ciclesonide C max below 30 pg/mL.
Distribution
Following IV administration, Vd of ciclesonide and des-ciclesonide are approximately 2.9 and 12.1 L/kg, respectively, and protein binding averages at least 99% for ciclesonide and its metabolite.
Metabolism
Des-ciclesonide is metabolized in the liver by the CYP3A4 isozyme and, to a lesser degree, CYP2D6.
Elimination
After IV administration, predominantly excreted in the feces (66%) and approximately 20% or less in the urine.
Special Populations
Hepatic Function Impairment. When administered by oral inhalation, dosage adjustments are not needed in patients with hepatic function impairment.
Ciclesonide Adverse Reactions / Ciclesonide Side Effects
CNS
Headache (7%).
EENT
Nasopharyngitis (7%); epistaxis (5%); pharyngolaryngeal pain (3%); ear pain (2%).
Precautions
Monitor
Closely monitor patients with a change in vision and with a history of glaucoma or cataracts.
Other Drug Interactions
Ketoconazole
May increase des-ciclesonide exposure by about 3.6-fold. Coadminister with caution.
Other Interactions
Information Not Available
Dosage
Perennial Allergic Rhinitis Adults and Children 12 years of age and older.
Nasal inhalation 200 mcg/day administered as 2 sprays (50 mcg/spray) in each nostril once daily (max, 200 mcg/day).
Seasonal Allergic Rhinitis Adults and Children 6 years of age and older.
Nasal inhalation 200 mcg/day administered as 2 sprays (50 mcg/spray) in each nostril once daily (max, 200 mcg/day).
List of Contraindications
Ciclesonide and Pregnancy
Caution when used during pregnancy
Ciclesonide and Lactation
Caution when used during lactation
Ciclesonide and Other Contraindications
Standard considerations
Storage
Store at 59° to 86°F. Do not freeze
